{"query": "Chronic disease as nested control-system failure — a hardene", "count": 20, "results": [{"id": "card_n_e41105aaa59f", "title": "Chronic disease as nested control-system failure — a hardened, falsifiable framework", "shelf": "science", "surface": "secular", "snippet": "Matt's public-domain framework: chronic disease is not one broken part but a failure somewhere in a\nNESTED CONTROL SYSTEM — five layers, each regulating the one below: (1) Cellular stress response →\n("}, {"id": "card_src_word_chronic_kidney_failure", "title": "chronic kidney failure", "shelf": "dictionary", "surface": "secular", "snippet": "chronic kidney failure: (noun) renal failure that can result from a variety of systemic disorders — syn: chronic renal failure"}, {"id": "card_src_word_chronic_renal_failure", "title": "chronic renal failure", "shelf": "dictionary", "surface": "secular", "snippet": "chronic renal failure: (noun) renal failure that can result from a variety of systemic disorders — syn: chronic kidney failure"}, {"id": "card_c_m_d49ce01f34d7", "title": "Nested Control Systems — a pre-registered falsification program (NHANE demonstrates The nested control-systems rule: meet a failure at its own layer", "shelf": "connections", "surface": "secular", "snippet": "the nested-control validity rules, worked and sealed in The Works"}, {"id": "card_c_b0c0bef4b323", "title": "The three doors the disease framework could  ↔ Chronic disease as nested control-system fai", "shelf": "connections", "surface": null, "snippet": "the evidence base is autonomic dysregulation in ASD — extending it to ALL chronic disease is a HYPOTHESIS, flagged as untested outside its home turf  — a concord the card itself states; mined + verifi"}, {"id": "card_ncs_l4_autonomic_actuators", "title": "Autonomic Nervous System — the actuators", "shelf": "regulation", "surface": "secular", "snippet": "Level 4 of the Nested Control-Systems stack. The physical state actuators: sympathetic/parasympathetic branches are the downstream effectors of hierarchical command, not the primary drivers of dysregu"}, {"id": "card_src_word_chronic_obstructive_pulmonary_disease", "title": "chronic obstructive pulmonary disease", "shelf": "dictionary", "surface": "secular", "snippet": "chronic obstructive pulmonary disease: (noun) a nonreversible lung disease that is a combination of emphysema and chronic bronchitis; usually patients have been heavy cigarette smokers"}, {"id": "card_c_1b902325c7f1", "title": "Chronic disease as nested control-system fai ↔ Cohesion and fracture — the mechanism of hol", "shelf": "connections", "surface": null, "snippet": "The framework aligns with genetic heterogeneity patterns and the \"cohesion law\" (a body held by nested bonds, failing at threshold).  — a concord the card itself states; mined + verified."}, {"id": "card_works_nested_control", "title": "The nested control-systems rule: meet a failure at its own layer", "shelf": "the-works", "surface": "secular", "snippet": "From Matt's Nested Control-Systems Framework: regulation is a stack of layers, and the layers do not compete — they nest. Two validity rules follow, and the engine checks them. First, a failure at a h"}, {"id": "card_ncs_l1_predictive_processing", "title": "Predictive Processing / Active Inference", "shelf": "regulation", "surface": "secular", "snippet": "Level 1 of the Nested Control-Systems stack. The computational frame: the brain minimizes prediction error and selects policies; autonomic shifts are action policies, meltdowns a cascading precision-a"}, {"id": "card_src_word_p_a_system", "title": "p.a. system", "shelf": "dictionary", "surface": "secular", "snippet": "p.a. system: (noun) an electronic amplification system used as a communication system in public areas — syn: public address system, PA system, P.A., PA"}, {"id": "card_c_0d8e7c4ee319", "title": "Reading the body's dashboard — HRV, pupil, s ↔ Chronic disease as nested control-system fai", "shelf": "connections", "surface": null, "snippet": "This is why the dashboard, read correctly, is a feedback SIGNAL (like every control system's sensor loop) rather than a diagnosis.  — a concord the card itself states; mined + verified."}, {"id": "card_src_word_pa_system", "title": "pa system", "shelf": "dictionary", "surface": "secular", "snippet": "pa system: (noun) an electronic amplification system used as a communication system in public areas — syn: public address system, P.A. system, P.A., PA"}, {"id": "card_ncs_l3_neurovisceral_integration", "title": "Neurovisceral Integration / Central Autonomic Network", "shelf": "regulation", "surface": "secular", "snippet": "Level 3 of the Nested Control-Systems stack. The executive-autonomic control loop: the prefrontal-vagal brake governs state switching; HRV/RSA is a direct efficiency index of that inhibitory loop (low"}, {"id": "card_src_word_public_address_system", "title": "public address system", "shelf": "dictionary", "surface": "secular", "snippet": "public address system: (noun) an electronic amplification system used as a communication system in public areas — syn: P.A. system, PA system, P.A., PA"}, {"id": "card_src_word_uninominal_system", "title": "uninominal system", "shelf": "dictionary", "surface": "secular", "snippet": "uninominal system: (noun) based on the principle of having only one member (as of a legislature) selected from each electoral district — syn: uninominal voting system, single-member system, scrutin un"}, {"id": "card_src_word_scrutin_uninomial_system", "title": "scrutin uninomial system", "shelf": "dictionary", "surface": "secular", "snippet": "scrutin uninomial system: (noun) based on the principle of having only one member (as of a legislature) selected from each electoral district — syn: uninominal system, uninominal voting system, single"}, {"id": "card_src_word_single_member_system", "title": "single-member system", "shelf": "dictionary", "surface": "secular", "snippet": "single-member system: (noun) based on the principle of having only one member (as of a legislature) selected from each electoral district — syn: uninominal system, uninominal voting system, scrutin un"}, {"id": "card_src_word_uninominal_voting_system", "title": "uninominal voting system", "shelf": "dictionary", "surface": "secular", "snippet": "uninominal voting system: (noun) based on the principle of having only one member (as of a legislature) selected from each electoral district — syn: uninominal system, single-member system, scrutin un"}, {"id": "card_src_word_scrutin_uninominal_voting_system", "title": "scrutin uninominal voting system", "shelf": "dictionary", "surface": "secular", "snippet": "scrutin uninominal voting system: (noun) based on the principle of having only one member (as of a legislature) selected from each electoral district — syn: uninominal system, uninominal voting system"}]}